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- Vesicular monoamine transporter 2 - Wikipedia
VMAT2 is an integral membrane protein that transports monoamines —particularly neurotransmitters such as dopamine, norepinephrine, serotonin, and histamine —from cellular cytosol into synaptic vesicles [6]
- List of VMAT2 inhibitors - Drugs. com
VMAT2 inhibitors (vesicular monoamine transporter-2 inhibitors) are used to treat movement disorders such as Huntington’s disease or tardive dyskinesia
- Transport and inhibition mechanisms of human VMAT2 - Nature
Here we describe cryo-electron microscopy structures of human VMAT2 complexed with serotonin and three clinical drugs at 3 5–2 8 Å, demonstrating the structural basis for transport and inhibition
- Vesicular Monoamine Transporter 2 (VMAT2) Inhibitors
The vesicular monoamine transporter type 2 (VMAT2) inhibitors are agents that cause a depletion of neuroactive peptides such as dopamine in nerve terminals and are used to treat chorea due to neurodegenerative diseases (such as Huntington chorea) or dyskinesias due to neuroleptic medications (tardive dyskinesia)
- The vesicular monoamine transporter 2: an underexplored pharmacological . . .
In the monoamine system, this process is carried out by the vesicular monoamine transporters (VMAT1 and VMAT2) These proteins are responsible for vesicular packaging of dopamine, norepinephrine, serotonin, and histamine
- Vesicular Monoamine Transporter 2 - an overview - ScienceDirect
VMAT2, the isoform found in the brain, shows modest substrate specificity and transports catecholamines and indoleamines, as well as histamine, into vesicles Both VMATs are Mg 2+ -dependent and are inhibited by reserpine, a drug that disrupts vesicular storage of monoamines (Henry et al , 1998)
- Structural mechanisms for VMAT2 inhibition by tetrabenazine
eLife assessment The report presents the cryo-EM structure of human vesicular monoamine transporter 2 (VMAT2) bound to tetrabenazine, a clinical drug VMAT2 is critical for neurotransmission, and the study constitutes an important milestone in neurotransmitter transport research
- VMAT2 Inhibitor: Role, Mechanisms, and Effects - BiologyInsights
VMAT2 inhibitors regulate neurotransmitter storage and release in the brain They are primarily used to manage movement disorders like Huntington’s disease and tardive dyskinesia by reducing excessive dopamine activity
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