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- Variant of Uncertain Significance (VUS)
When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
- What to do if your genetic test finds a variant of uncertain . . .
But sometimes, you might not get a clear “yes” or “no ” You might just get a “maybe ” “That’s what you’ll hear if you have a variant of uncertain significance, or VUS for short,” says Sara Wofford, a genetic counselor at MD Anderson The Woodlands
- Genetic Test Result: VUS - Variant of Uncertain Significance
A VUS result could get changed to either benign or pathogenic with new information For some variants, a different test can measure if the gene is working or not
- VUS Variant of Uncertain Significance for cancer patients - MC1185-82
Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known
- What Is a VUS? Variants of Unknown Significance in Genetic Testing and . . .
What to do if your genetic test results include a VUS If you have one or more VUSs in your genetic test results, the most important next step is to talk with a neuromuscular specialist or genetic counselor They can look at the whole picture and decide what, if anything, to do next
- Assessing a Variant of Uncertain Significance (VUS)
Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation
- VUS Genetics — Functional variant classification, powered by geneSlice
Most gene variants in cancer and rare disease are Variants of Uncertain Significance (VUS), leaving targeted therapies out of reach for patients who could benefit
- Rates and Classification of Variants of Uncertain Significance in . . .
In general, VUS rates were highest in individuals who were not of European White descent (eg, Asian, Black, Hispanic, Native American, Pacific Islander, and Sephardic Jewish) and in genes associated with disorders of incomplete penetrance
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