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- Variant of Uncertain Significance (VUS)
When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
- What to do if your genetic test finds a variant of uncertain . . .
But sometimes, you might not get a clear “yes” or “no ” You might just get a “maybe ” “That’s what you’ll hear if you have a variant of uncertain significance, or VUS for short,” says Sara Wofford, a genetic counselor at MD Anderson The Woodlands
- VUS Variant of Uncertain Significance for cancer patients . . .
Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known
- Understanding genetic variants of uncertain significance - PMC
Variants with insufficient or conflicting evidence supporting disease association, such that they cannot be classified as ‘pathogenic likely pathogenic’, nor as ‘benign likely benign’, are VUSs The presence of a VUS, even in a relevant gene or chromosome, does not confirm a genetic diagnosis
- Assessing a Variant of Uncertain Significance (VUS)
Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation
- VUS – The Most Maligned Result in Genetic Testing
The classification of genetic variants, based on the ACMG guidelines, is usually a five-tiered scheme which describes the quantity and quality of evidence needed to classify the variant as pathogenic, likely pathogenic, a variant of uncertain significance (VUS), likely benign, or benign
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