安裝中文字典英文字典辭典工具!
安裝中文字典英文字典辭典工具!
|
- Pathology Outlines - HPV independent VIN-vulva
Subtypes include p53 mutant differentiated vulvar intraepithelial neoplasia (dVIN) and p53 wild type lesions such as differentiated exophytic vulvar intraepithelial lesion (DEVIL) and vulvar acanthosis with altered differentiation (VAAD), recently also designated as vulvar aberrant maturation (VAM) or HPV independent, p53 wild type verruciform
- Pathology Outlines - HPV associated SIL
Answer E is incorrect because the p53 pattern in basal sparing pattern is inconsistent and the p53 wild type pattern can be found in certain variants of HPV independent vulvar intraepithelial neoplasia Answer C is incorrect because, although rare, block-like p16 positivity can occasionally be seen in dVIN as well Comment Here
- What’s new in gynecologic pathology 2021: vulva, cervix, and uterus
(dVIN) Its presumed rapid progression to invasive carcinoma and the difficulties in its diagnosis likely explain why dVIN represents only <10% of squamous intraepithelial lesions - dVIN is characterized by negative or patchy p16 and mutant-type p53 expression (the latter could be full-thickness strong, basal
- Pathology Outlines - Lichen sclerosus
Other terminology: differentiated VIN (dVIN), differentiated exophytic vulvar intraepithelial lesion (DEVIL), vulvar acanthosis with altered differentiation (VAAD), vulvar altered maturation (VAM) Shows epithelial hyperplasia and loss of normal maturation; often shows significant basal atypia and may show mutant pattern p53 immunostaining ( Mod
- HPV independent squamous cell carcinoma-vulva
Coincident HPV independent vulvar intraepithelial neoplasia (dVIN, vaVIN) (desirable) Terminology
- Pathology Outlines - PathologyOutlines. com
Pathology Outlines - PathologyOutlines com
- WHAT’S NEW IN PATHOLOGY? - PathologyOutlines. com
intraepithelial neoplasia (dVIN) Its presumed rapid progression to invasive carcinoma and the difficulties in its diagnosis likely explain why dVIN represents only <10% of squamous intraepithelial lesions • dVIN is characterized by negative or patchy p16 and mutant-type p53 expression (the latter could be full-thickness strong, basal strong,
- Pathology Outlines - p53
Stains - p53, Tumor suppressor gene at 17p13, 53 kDa Tumor suppressor gene at 17p13, 53 kDa p53 ensures that cells repair any damaged DNA before cell division by inducing cell cycle arrest to allow time for DNA repair or to force the cell to undergo apoptosis via activation of BAX gene (J Biomed Biotechnol 2011;2011:603925, Cancers (Basel) 2018;10:135)
|
|
|