Knockout Mice Fact Sheet - National Human Genome Research . . . To produce knockout mice, researchers use one of two methods to insert artificial DNA into the chromosomes contained in the nuclei of ES cells Both methods are carried out in vitro, that is in cultured cells grown in laboratory conditions
Knockout animal: Production of knockout mice Knockout animal . . . Knockout animal: A knockout animal is a laboratory animal in which researchers have inactivated or knocked out, an existing gene by replacing the gene or disrupting it with an artificial piece of DNA Since most of the knockout animals are developed using mice, we will discuss the production and uses of knockout animals with respect to mice