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- IL-17 and IL-17-producing cells in protection versus pathology
IL-17A and IL-17F are produced by CD4 + and CD8 + T cells, γδ T cells, and various innate immune cell populations in response to IL-1β and IL-23, and they mediate protective immunity
- The paradigm of IL-23-independent production of IL-17F and IL-17A and . . .
IL-17A and IL-17F are produced by cells of the innate and adaptative immune system and activate the production of inflammatory mediators such as tumor necrosis factor α (TNFα), IL-1β, IL-6, granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF)
- Interleukin-17A and Interleukin-17F: A Tale of Two Cytokines
IL-17A and IL-17F induce IL-6, CCL3, and G-CSF by peritoneal macrophages, but IL-17A also induced proinflammatory cytokines such as IL-1β, IL-12p70, and GM-CSF (shown in red)
- Interleukin-17A and Interleukin-17F: A Tale of Two Cytokines
IL-17A and IL-17F induce IL-6, CCL3, and G-CSF by peritoneal macro-phages, but IL-17A also induced proinflammatory cytokines such as IL-1b, IL-12p70, and GM-CSF (shown in red)
- The IL-17 Story The IL-17 Story: A - ucbcompass. com
Protective immunity after epidermal Candida colonization requires both IL-17A and IL-17F Candida albicans CFUs in the skin of WT, Il17a − −, Il17f − −,and Il17af − − mice on Day 7 after inoculation
- IL-17 in the Pathogenesis of Disease: Good intentions gone awry
An independent study has verified that commensal-driven gut Th17 cells express IL-17, IL-22 and IL-10 and further identified that they are uniquely dependent on DC expression of the C-type lectin receptor Mincle, which induces IL-6 and IL-23 expression (31)
- IL-17: Chronic Inflammation Autoimmune Risk with IL17A, IL17F
Genetic variants that increase the body’s production of IL-17A are a risk factor for inflammatory bowel disease (IBD), psoriasis, rheumatoid arthritis, bronchitis severity, gastric cancer, and more
- Functional Specialization of Interleukin-17 Family Members
In addition, IL-17A is produced by intestinal Paneth cells (Takahashi et al , 2008), whereas IL-17F mRNA, but not IL-17A mRNA, is expressed in colonic epithelial cells (Ishigame et al , 2009), suggesting that IL-17A and IL-17F from nonlymphoid cells may also regulate immune responses
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