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- Cutting Edge: Active TGF-β1 Released from GARP TGF-β1 Complexes on the . . .
We identified a new mechanism operating on the surface of human regulatory T cells and involving membrane protein GARP, which binds latent TGF-β1 The paracrine activity of regulatory T cell–derived TGF-β1 contributes to immunosuppression and can be inhibited with anti-GARP Abs
- Dynamic Regulation of Tgf-B Signaling by Tif1 A Computational . . . - PLOS
We show that TGF-b signaling is highly sensitive to the TIF1c Smad4 ratio, suggesting a critical role for the FAM UPS9x deubiquitinase This model also predicts how varying TIF1c Smad4 ratios can modulate the cellular response to transient and sustained TGF-b stimulation, accounting for a highly graded TGF-b response
- TGF-β stimulation in human and murine cells reveals commonly affected . . .
The complex and sometimes contradicting mechanisms by which TGF-β yields phenotypic effects are not yet completely understood In this study we investigated and compared the transcriptional response profile of TGF-β1 stimulation in different cell types
- Virtual Screening, Molecular Docking, and Dynamic . . . - Springer
The current study aims to investigate possible inhibitors targeting TGF-β1 using molecular docking and dynamic simulations To target TGF-β1, we used anti-cancer drugs and small molecules
- Comprehensive characterization of TGFB1 across hematological . . . - Nature
Our results suggest that TGFB1 is broadly dysregulated in hematological malignancies TGFB1 might regulate the immune microenvironment in a cancer‐type‐specific manner, which could be
- Human Transforming Growth Factor Beta 1 High: Effects on Health
Pro-inflammatory mediators like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) stimulate TGFB1 gene expression A study in The Journal of Immunology found that macrophage-derived IL-6 enhances TGF-β1 secretion in fibroblasts, amplifying tissue remodeling
- Transforming growth factor– 1 in regulatory T cell biology - Science
Although a preponderance of evidence indicates no essential roles for Treg-derived TGF- 1 in Treg immunosuppression, TGF- 1 signaling is crucial for Treg development in the thymus and periphery Furthermore, active TGF- 1 instructs the differentiation of other T cell subsets, including TH17 cells
- TGFβ-induced fibroblast activation requires persistent and targeted . . .
We identified pracinostat, an HDAC inhibitor, as a potent attenuator of lung fibroblast activation and confirmed its efficacy in patient-derived fibroblasts isolated from fibrotic lung tissue Mechanistically, we found that HDAC-dependent transcriptional repression was an early and essential event in TGFβ-mediated fibroblast activation
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