ApolipoproteinE3(ApoE3)butNotApoE4Protectsagainst . . . - Synaptogen Synaptic loss is the earliest pathological change in Alzheimer disease (AD) and is the pathological change most directly corre-lated with the degree of dementia ApoE4 is the major genetic risk factor for the age-dependent form of AD, which accounts for 95% of cases Here we show that in synaptic networks formed from primary hippocampal neurons in culture, apoE3, but not apoE4, prevents the
Towards universal therapeutics for memory disorders - Synaptogen Apolipoprotein E (ApoE) is a critical signal for synaptogen-esis and synaptic maturation [101] ApoE cholesterol com-plex released from astrocytes is taken up through low-density lipoprotein receptor-related protein 1 (LRP1) and activates PKCe synthesis in neurons [102], thereby acti-vating PKC-dependent neuronal repair pathways