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- ESCC and GC GEJC Treatment | TEVIMBRA® (tislelizumab-jsgr)
cancer of the stomach (gastric cancer) or cancer where the esophagus joins the stomach (gastroesophageal junction cancer) TEVIMBRA may be used in combination with chemotherapy that contains platinum and fluoropyrimidine as your first treatment when your gastric or gastroesophageal junction cancer:
- FDA Approves Tevimbra Combination for Gastric or Gastroesophageal . . .
Tevimbra is a type of precision cancer medicine This humanized IgG4 anti-PD-1 monoclonal antibody was designed specifically to minimize binding to FcγR on macrophages RATIONALE-305 Investigators Tislelizumab plus chemotherapy versus placebo plus chemotherapy as first line treatment for advanced gastric or gastro-oesophageal junction
- Tevimbra Plus Chemo May Be Safe, Effective in Advanced Gastric GEJ Cancer
Tevimbra plus POFI demonstrated high efficacy with a 93 5% objective response rate and 100% disease control rate in advanced gastric cancer Median progression-free survival was 10 51 months, and overall survival was 14 75 months, indicating promising outcomes The treatment regimen was well
- TEVIMBRA Received FDA Approval as First-Line Therapy for Gastric and . . .
The prognosis for patients with gastric or GEJ cancer depends on the stage at diagnosis, treatment response, and overall health Immunotherapies, such as TEVIMBRA (tislelizumab), offer a promising approach for first-line treatment in patients with PD-L1 positive advanced or metastatic gastric and GEJ cancers These newer treatments are vital
- FDA Approves Tislelizumab Chemo in Gastric GEJ Adenocarcinoma
The FDA previously accepted a biologics license application BLA for tislelizumab plus chemotherapy to treat patients with locally advanced or metastatic gastric or GEJ adenocarcinoma in February 2024 4 References TEVIMBRA approved in U S for first-line treatment of gastric and gastroesophageal junction cancers in combination with chemotherapy
- FDA Approval of Tislelizumab Plus Chemo Offers a New Option in Advanced . . .
Along with the efficacy data supporting the use of tislelizumab-jsgr (Tevimbra) in combination with chemotherapy for the treatment of patients with PD-L1–positive advanced gastric or
- TEVIMBRA® (tislelizumab-jsgr) for Gastric or Gastroesophageal Junction . . .
Treatment of gastric cancer often uses endoscopic resection, which may be curative in the early stages of the disease Given the high rate of relapse, neoadjuvant and adjuvant chemotherapy has become standard practice due to the robust data indicating increased rates of survival post-resection 1 Several targeted therapies and immunotherapies that increase patients’ overall survival in the
- Tevimbra Approved in U. S. for First-line Treatment of Gastric and . . .
In the U S , it is estimated that there were approximately 27,000 patients diagnosed with gastric cancer and 11,000 deaths from the disease in 2024 2 The five-year survival rate for gastric cancer in the U S is 36% 3 Gastroesophageal junction cancer occurs where the esophagus joins the stomach, which is just beneath the diaphragm (the thin
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