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- The Granuloma in Tuberculosis: Dynamics of a Host–Pathogen . . .
Abstract A granuloma is defined as an inflammatory mononuclear cell infiltrate that, while capable of limiting growth of Mycobacterium tuberculosis, also provides a survival niche from which the bacteria may disseminate The tuberculosis lesion is highly dynamic and shaped by both, immune response elements and the pathogen In the granuloma, M tuberculosis switches to a non-replicating but
- Understanding the development of tuberculous granulomas
To help shed light on determinants of protective and non-protective TB granulomas, we also compared the TB granulomatous response and other pathologic lung lesions in various animals naturally or experimentally infected with Mycobacterium tuberculosis (Mtb), other Mtb complex species, or a mycobacterial surrogate with that of human pulmonary TB
- Decoding the tuberculous granuloma - ScienceDirect
Central to tuberculosis (TB) is a complex structure called the granuloma, a characteristic collection of immune cells organized around central sites of mycobacterial infection (Pagan and Ramakrishnan, 2018) Granulomas provide a key pathogen-host interface during Mycobacterium tuberculosis infection Rather than being static structures, granulomas remodel in different ways throughout infection
- Understanding the tuberculosis granuloma: the matrix . . .
Mycobacterium tuberculosis (Mtb) causes the human disease tuberculosis (TB) and remains the top global infectious pandemic after coronavirus disease 2019 (COVID-19) Furthermore, TB has killed many more humans than any other pathogen, after
- Revisiting the role of the granuloma in tuberculosis
However, the large number of tuberculosis cases worldwide indicates that many individuals fail to eradicate infection through granuloma formation More people have died of tuber-culosis than any other infectious disease throughout history, and more people have tuberculosis today than at any other time in history27
- Tuberculosis Granuloma Atlas | Harvard Tissue Atlas
The Tuberculosis Granuloma Atlas aims to understand the biology of granulomas, sites of chronic lung inflammation shaped by the biology Mycobacterium tuberculosis (Mtb) and host immune responses Within a granuloma, Mtb growth is often limited, but this provides a niche from which bacteria can subsequently disseminate The project also aims to build capacity for digital pathology in low and
- Unraveling the role of the immune landscape in tuberculosis . . .
Despite significant advances in research over the past century, Tuberculosis (TB) remains a formidable global health concern TB granulomas are organized structures composed of immune cells, that serve as the body's primary defense against the spread of Mycobacterium tuberculosis (Mtb) The immune landscape of TB granulomas involves a complex array of immune cells, including CD4+ and CD8 + T
- Understanding the development of tuberculous granulomas . . .
Granulomas, organized aggregates of immune cells which form in response to Mycobacterium tuberculosis (Mtb), are characteristic but not exclusive of tuberculosis (TB) Despite existing investigations on TB granulomas, the determinants that differentiate host-protective granulomas from granulomas that contribute to TB pathogenesis are often
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