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- Basophils and allergic inflammation - PMC - PubMed Central (PMC)
These data, along with the ability of TSLP-elicited basophils to promote IgE-independent inflammation, provoke the hypothesis that TSLP-elicited basophils may contribute the pathogenesis of EoE via a distinct mechanism from the IgE-dependent pathways that contribute to classical food allergy
- Basophils and their effector molecules in allergic disorders
In this review, we highlight the recent advances in the field of basophil biology with a particular focus on the role of basophils in allergic inflammation Further studies on basophils and their effector molecules will help us identify novel therapeutic targets for treating allergic disorders
- New Insights into the Roles for Basophils in Acute and Chronic Allergy
In response to the allergen-IgG immune complexes, basophils release the platelet-activating factor rather than histamine as the major chemical mediator to induce the systemic anaphylaxis The depletion of basophils protects mice from death due to anaphylactic shock
- Basophils and their effector molecules in allergic disorders
In this review, we highlight the recent advances in the field of basophil biology with a particular focus on the role of basophils in allergic inflammation Further studies on basophils and their effector molecules will help us identify novel therapeutic targets for treating allergic disorders
- Important and specific role for basophils in acute allergic reactions
We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response
- Basophils and allergic inflammation - Journal of Allergy and Clinical . . .
For example, basophils are thought to contribute to the pathogenesis of allergic contact dermatitis, 1 atopic dermatitis (AD), 2 allergic drug reactions, 3 immediate hypersensitivity reactions (eg, anaphylaxis), 3 asthma, 4-6 bullous pemphigoid, 2 lupus nephritis, 7 Crohn disease, 3 skin and kidney allograft responses, 8,9 and acute and chronic
- Emerging roles of basophils in allergic inflammation
Basophils are known to produce large amounts of IL-4 in response to various stimuli Basophil-derived IL-4 has recently been shown to play versatile roles in allergic inflammation by acting on various cell types, including macrophages, innate lymphoid cells, fibroblasts, and endothelial cells
- Important and specific role for basophils in acute allergic reactions . . .
We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response
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