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- The haplotype-resolved genome assembly of autotetraploid rhubarb Rheum . . .
By assembly of an autotetraploid medicinal plant genome, our study offers unprecedented genomic resources for fundamental research and identification of genes associated with agronomically relevant traits and can guide the utilization, improvement, and polyploid breeding of rhubarb
- The haplotype-resolved genome assembly of autotetraploid rhubarb Rheum . . .
Analysis of a 7 68-Gb haplotype-resolved autotetraploid Rheum officinale genome indicates that transposable elements have made significant contributions to its genome evolution, gene copy number variation, and gene expression, particularly with regard to metabolite biosynthesis
- The haplotype-resolved genome assembly of autotetraploid rhubarb Rheum . . .
Combining genomics, transcriptomics, and metabolomics, we explored the contributions of gene family amplification and tetraploidization to the abundant anthraquinone production of R officinale, as well as gene expression patterns and differences in anthraquinone content among tissues
- 河北大学杜会龙团队构建药用大黄高质量同源四倍体基因组并 . . .
该研究构建了药用大黄高质量的同源四倍体基因组，探究了蓼科植物如荞麦和藜科植物的 基因组进化 与重要基因家族的演化，解析了 转座子 在基因组进化、基因拷贝数变异和基因表达调控中的重要作用，并揭示了药用大黄根中高蒽醌含量的遗传学基础。 本研究结合PacBio HiFi、Oxford Nanopore和Hi-C等测序技术对药用大黄进行基因组测序组装，得到了7 68Gb基因组序列（contig N50 3 47Mb，包含2n=4x=44条 染色体），其中约为83%为 重复序列，这也是药用大黄单倍体基因组（1 92 Gb）远大于苦荞麦基因组（0 49 Gb）的主要原因。 同时，该研究还通过药用大黄以及其它同源和异源多倍体植物亚基因组间系统的比较分析，明确了药用大黄为同源四倍体。 图1
- 单倍型解析的自交系大黄基因组组装为了解其基因组进化和蒽 . . .
Rheum officinale是《中国药典》中记载的官方大黄中唯一的四倍体（2n = 4x = 44），因其有效成分丰富、品质优良、环境适应性强而被全球广泛使用。
- The haplotype-resolved genome assembly of autotetraploid . . .
We placed the recent autotetraploidization of R officinale at ∼0 58 mya and analyzed the genomic features of its homologous chromosomes
- 经典案例 | 同源四倍体大黄基因组揭示蒽醌类物质进化和积累 . . .
近期，河北大学生命科学学院杜会龙教授团队在Plant Communications上发表了最新研究成果，通过基因组、转录组和代谢组分析全面概述了基因家族扩张和四倍体化对大黄中丰富蒽醌含量的影响。 The haplotype-resolved genome assembly of autotetraploid rhubarb Rheum officinale provides insights into the genome evolution and massive accumulation of anthraquinones 大黄 (Rheum officinale)是大黄属 蓼科多年生草本植物，数千年来被列入许多经典中药配方中，含大黄的中成药有900多种，中国大黄年需求量约5500吨。
- The haplotype-resolved genome assembly of autotetraploid . . .
Analysis of a 7 68-Gb haplotype-resolved autotetraploidRheum officinalegenome indicates that transposable elements have made significant contributions to its genome evolution, gene copy number variation, and gene expression, particularly with regard to metabolite biosynthesis
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