Discovery of Staphylococcus aureus Sortase A Inhibitors Using . . . Here, we report the identification of several inhibitors of sortase A using virtual screening methods that employ the relaxed complex scheme, an advanced computer-docking methodology that accounts for protein receptor flexibility Experimental testing validates that several compounds identified in the screen inhibit the activity of sortase A
Soft, stretchable, fully implantable miniaturized . . . - PubMed In this report we bypass these limitations using technologies that combine thin, mechanically soft neural interfaces with fully implantable, stretchable wireless radio power and control systems The resulting devices achieve optogenetic modulation of the spinal cord and peripheral nervous system
Inhibition of sortase-mediated Staphylococcus aureus adhesion . . . The sortase enzymes are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer In Staphylococcus aureus, deletion of the sortase isoforms results in marked reduction in virulence and infection potential, making it an important antivirulence target Recombinant sortase A (SrtA) and sortase B (SrtB) were
Nanogenerators facilitated piezoelectric and flexoelectric . . . Here, we report the nanogenerators that enable a facile characterization of piezoelectricity and flexoelectricity in the device scale The quadrant electrode NG along with nematically organized M13 bacteriophage provides the comprehensive piezoelectric coefficients while the flexoelectric coefficient was extracted from sandwich electrode NG
Stretchable and biodegradable self-healing conductors for . . . Here, we introduce a stretchable, biodegradable, self-healing conductor constructed by combination of two layers: (i) synthetic self-healing elastomer and (ii) self-healing conductive composite with additives