USC vs Oregon Prediction and Preview: College Football 2025 . . . USC vs Oregon Preview Nov 15, 2025; Los Angeles, California, USA; Southern California Trojans wide receiver Makai Lemon (6) celebrates his touchdown scored against the Iowa Hawkeyes with running back Bryan Jackson (21) during the second half at the Los Angeles Memorial Coliseum
No. 6 Oregon vs. No. 16 USC prediction: Odds, expert picks . . . Game Details and How to Watch No 16 USC at No 6 Oregon Date: Saturday, November 22, 2025 Time: 3:30PM Eastern Site: Autzen Stadium City: Eugene, OR TV Streaming: CBS Game Odds for No 6 Oregon vs No 16 USC The latest odds as of Thursday courtesy of DraftKings: Moneyline: USC Trojans (+295), Oregon Ducks (-375) Spread: Oregon -9 5 (-112)
USC vs. Oregon Odds, Preview, Picks, and Prediction This USC vs Oregon prediction highlights a Trojans team that's 6-1 in Big Ten play (tied for third place) and 2-2 on the road, and a Ducks squad that's also 6-1 in conference competition and 5-1 at home Saturday's matchup marks the 64th college football game between Southern Cal and Oregon