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Phorbol-12-myristate-13-acetate-induced protein 1 - Wikipedia Bcl-2 family members can form hetero- or homodimers, and they act as anti- or pro- apoptotic regulators that are involved in a wide variety of cellular activities The expression of Noxa is regulated by the tumor suppressor p53, and Noxa has been shown to be involved in p53-mediated apoptosis
NOXA the BCL-2 Family Member behind the Scenes in Cancer Treatment NOXA is a critical mediator of stress responses to anticancer drugs This BH3-only protein sets the apoptotic threshold in cancer cells in response to chemotherapies by counteracting the prosurvival BCL-2 family protein MCL-1
Noxa: at the tip of the balance between life and death - PMC Regulation of Noxa expression Initial observations indicated that Noxa is a primary p53-response gene Noxa mRNA is rapidly induced after adenovirus-mediated introduction of p53 into MEF derived from p53− − or wt mice and in wt thymocytes subjected to γ-irradiation but in not p53− − controls
NOXA (@noxa. official) • Instagram photos and videos 56K Followers, 348 Following, 1,596 Posts - NOXA (@noxa official) on Instagram: "Playing Fast since 2002 🇮🇩 Guitar : @ade noxa Vocal : @diegoshefa Bass : @biomantaradipa Drum : @xalvinx Check our info 👇"
Noxa: Role in Cancer Pathogenesis and Treatment - PubMed Noxa induces apoptosis via p53-dependent and or p53-independent mechanisms While Noxa may play a limited role in apoptosis, it is a crucial player that interacts with several proteins in the apoptosis pathway, highlighting its importance in the pathogenesis and treatment of certain cancers
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