Uterine overdistention induces preterm labor mediated by inflammation . . . Uterine overdistention is thought to induce preterm labor in women with twin and multiple pregnancies, but the pathophysiology remains unclear We investigated for the first time the pathogenesis of preterm birth associated with rapid uterine distention in a pregnant nonhuman primate model
Alveolar overdistension is an important mechanism of persistent lung . . . Possible causes include overdistension of aerated alveoli by inappropriately large tidal volumes (volutrauma), shear stresses generated during the recruitment and de-recruitment of lung units at the junction of aerated and collapsed lung, and infective or ischaemic necrosis of persistently collapsed lung
Overdistension in ventilated children - PMC Ventilating patients with acute respiratory failure according to standardized recommendations can lead to varying volume–pressure (V-P) relationships and overdistension Young children may be more susceptible than adults to overdistension, and
Adjusting tidal volume to stress index in an open lung condition . . . Setting tidal volume to a non-injurious stress index in an open lung condition improves alveolar ventilation and prevents overdistension without increasing lung injury This is in comparison with limited Pplat protective ventilation in a model of lung injury with low chest-wall compliance
Cardiovascular manifestations of perioperative acute urinary bladder . . . Bladder over-distension may lead to undesirable autonomic manifestations such as vomiting, bradycardia, hypotension, hypertension, cardiac dysrhythmias, or even asystole [1] We report two clinically diverse cardiovascular presentations of acute bladder over-distension
The Role of Uterine Overdistension in Preterm Labor Induction Uterine distention in pregnancy is when the uterus expands to accommodate the growing fetus, placenta, and amniotic fluid While the uterus naturally undergoes enlargement during pregnancy, there are limits to how much it can stretch