Overman Rearrangement - Organic Chemistry Portal The Overman Rearrangement allows the conversion of readily available allylic alcohols into allylic amines by a two-step synthesis involving the rearrangement of an allylic trichloroacetimidate to an allylic trichloroacetamide with clean 1,3-transposition of the alkenyl moiety
Tsuji-Trost Reaction - Organic Chemistry Portal Tsuji-Trost Reaction Trost Allylation The Tsuji-Trost Reaction is the palladium-catalyzed allylation of nucleophiles such as active methylenes, enolates, amines and phenols with allylic compounds such as allyl acetates and allyl bromides
Cope Rearrangement - Organic Chemistry Portal Organic Chemistry Portal Reactions >> Name Reactions Further Information Literature Related Reactions Claisen Rearrangement Overman Rearrangement
Claisen Rearrangement - Organic Chemistry Portal Organic Chemistry Portal Reactions >> Name Reactions Further Information Literature Related Reactions Ireland-Claisen Rearrangement Cope Rearrangement Overman Rearrangement [2,3]-Wittig Rearrangement
Olefin Metathesis, Grubbs Reaction - Organic Chemistry Portal Olefin Metathesis Grubbs Reaction Olefin Metathesis allows the exchange of substituents between different olefins - a transalkylidenation This reaction was first used in petroleum reformation for the synthesis of higher olefins (Shell higher olefin process - SHOP), with nickel catalysts under high pressure and high temperatures Nowadays, even polyenes with MW > 250,000 are produced
Directed Ortho Metalation - Organic Chemistry Portal Directed ortho Metalation (DOM) The reaction of an alkyllithium compound with an arene bearing a "Directed Metalation Group" (DMG) normally leads to an ortho -metalated intermediate Good DMG's are strong complexing or chelating groups that have the effect of increasing the kinetic acidity of protons in the ortho -position The ortho -metalated intermediate can be reacted with a variety of
Henry Reaction - Organic Chemistry Portal Henry Reaction The Henry Reaction is a base-catalyzed C-C bond-forming reaction between nitroalkanes and aldehydes or ketones It is similar to the Aldol Addition, and also referred to as the Nitro Aldol Reaction If acidic protons are available (i e when R = H), the products tend to eliminate water to give nitroalkenes Therefore, only small amounts of base should be used if the isolation of
Ramberg-Bäcklund Reaction - Organic Chemistry Portal Ramberg-Bäcklund Reaction The Ramberg-Bäcklund Reaction allows a base-mediated conversion of α-halosulfones into E or Z alkenes Z alkenes are often observed with weak bases, whereas strong bases give predominantly E alkenes Myers' modification and newer synthetic protocols allow an in situ generation of α-halosulfones, so that the readily available sulfones can be used directly without
Upjohn Dihydroxylation - Organic Chemistry Portal Upjohn Dihydroxylation The Upjohn Dihydroxylation allows the syn -selective preparation of 1,2-diols from alkenes by the use of osmium tetroxide as a catalyst and a stoichiometric amount of an oxidant such as NMO (N -methyl morpholine- N -Oxide)