Pemphigus Vulgaris: A Complete Overview — DermNet Pemphigus vulgaris is a rare autoimmune disease that is characterised by painful blisters and erosions on the skin and mucous membranes, most commonly inside the mouth It accounts for 70% of all pemphigus cases worldwide Images below show mucosal lesions
Pemphigus Foliaceus: Causes, Symptoms and Images — DermNet The pemphigus family are rare autoimmune blistering diseases affecting the skin and mucous membranes The primary aim of treatment is to prevent bacterial infection; spontaneous remission may occur in patients while in others, the problem may persist for several years
Paraneoplastic pemphigus - DermNet Paraneoplastic pemphigus (PNP) is a rare, autoimmune, mucocutaneous, blistering disease that is almost always associated with a confirmed or occult neoplasm The cause of PNP is not completely understood
Hailey-Hailey disease (benign familial pemphigus) - DermNet What is benign familial pemphigus? Benign familial pemphigus is also known as Hailey–Hailey disease It is a rare hereditary blistering skin disease first described by the Hailey brothers in 1939 Unrelated to pemphigus vulgaris, Hailey-Hailey disease is not an autoimmune condition and has a differing prognosis
Bullous Pemphigoid: Causes, Symptoms, and Treatment — DermNet Bullous pemphigoid is the most common form of autoimmune subepidermal blistering disease Treatment for bullous pemphigoid is usually needed for several years In many cases, the pemphigoid eventually completely clears up, and the treatment can be stopped
IgA pemphigus - DermNet What is IgA pemphigus? IgA pemphigus (or immunoglobulin A pemphigus) is an autoimmune blistering disorder It is also called intercellular IgA dermatosis among other names IgA pemphigus has two major subtypes: Subcorneal pustular dermatosis (SPD) type Deposition of intracellular IgA against the glycoprotein desmocollin-1 seen predominantly in the upper epidermis Intraepidermal neutrophilic
Nikolskys Sign - DermNet Using Nikolsky’s original definition strictly, his eponymous sign is the physical splitting of the epidermis creating an erosion (partial loss of the epidermis) following the application of a shearing force to the surface of the skin seen in pemphigus foliaceus However, with time the use of the sign has broadened to include other intraepidermal disorders including pemphigus vulgaris and it
Drug-induced pemphigus - DermNet The diagnosis of pemphigus is confirmed by its characteristic intraepidermal blistering when seen on histology of a skin biopsy, and the presence of typical antibodies on direct immunofluorescence Circulating pemphigus antibodies against desmoglein 1 and or desmoglein 3 may be detected on serology How is drug-induced pemphigus treated?
Pemphigus vulgaris pathology - DermNet Pemphigus vulgaris is a chronic vesiculobullous skin disorder characterised by autoantibodies against desmoglein 3, which is a component of the desmosome (an intracellular adhesion molecule) Disruption of keratinocyte adhesion leads to superficial blistering and erosion affecting the skin and or mucous membranes Histology of pemphigus vulgaris Early lesions of pemphigus vulgaris show