Rare allergy to vibrations tied to faulty gene - Science | AAAS Research published online today in The New England Journal of Medicine describes a mutation in a gene called ADGRE2, found in 22 people with vibratory urticaria, but not in 14 of their unaffected relatives
ADGRE2 gene: MedlinePlus Genetics The ADGRE2 gene mutation that causes vibratory urticaria, written as Cys492Tyr or C492Y, replaces the protein building block (amino acid) cysteine with the amino acid tyrosine at position 492 of the protein sequence
Vibratory urticaria – Rare Dermatology News Vibratory urticaria is caused by changes (mutations) in the ADGRE2 gene and appears to be inherited in an autosomal dominant manner Treatment involves avoiding vibration stimulus and use of antihistamines
Genetic Cause Of Rare Allergy To Vibration Discovered Scientists at the National Institutes of Health (NIH) have identified a genetic mutation responsible for a rare form of inherited hives induced by vibration, also known as vibratory urticaria
Vibratory Urticaria Breakthrough: Genetic Cause Of Rare Allergy To . . . Scientists have identified a genetic mutation responsible for a rare form of inherited hives induced by vibration, also known as vibratory urticaria Running, hand clapping, towel drying or even taking a bumpy bus ride can cause temporary skin rashes in people with this rare disorder
Vibratory Urticaria Associated with a Missense Variant in ADGRE2 We identified a previously unknown missense substitution in ADGRE2 (also known as EMR2), which was predicted to result in the replacement of cysteine with tyrosine at amino acid position 492 (p C492Y), as the only nonsynonymous variant cosegregating with vibratory urticaria in two large kindreds