Hematopoietic stem cells from pluripotent stem cells . . . Differentiated cells can be reprogrammed to an embryonic‐like state with the groundbreaking discovery in 2006 of inducing pluripotent stem cells (PSCs) from mouse stromal cells after introducing four transcription factors (OCT4, SOX2, KLF4, and c‐Myc) using integrating viral vectors under ES cell culture conditions 10 This discovery
Hematopoietic stem cell - Wikipedia Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood [16] [17] [13] It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin)
Hematopoiesis from Pluripotent Stem Cells | Thermo Fisher . . . Hematopoietic progression—survival, proliferation, or differentiation—is well-supported by cytokines and growth factors The initial stages of pluripotent hematopoietic cell development is regulated by broadly acting cytokine groups growth factors such as IL-3 (interleukin-3), SCF (stem cell factor), GMCSF (granulocyte-macrophage colony-stimulating factor), IL-1 (interleukin-1), IL-6
Long-term engrafting multilineage hematopoietic cells . . . Hematopoietic stem cells (HSCs) derived from human induced pluripotent stem cells (iPS cells) have important biomedical applications We identified differentiation conditions that generate HSCs
Hematopoietic cell differentiation from embryonic and induced . . . Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system Establishment of pluripotent stem cells provides a