Metallothionein-dependent recovery of alcohol-related liver injury by . . . Alcohol-related liver disease is accompanied by hepatic zinc deficiency We synthesized a zinc-glutathione (ZnGSH) complex as a zinc delivery system to test the hypothesis that effective zinc supplementation can recover the liver from alcohol-related injury
Metallothioneins in the Pathogenesis of Liver Diseases: A Review These findings raise compelling questions about the potential application of MTs-based microbiome-targeted therapies in cholestatic liver diseases, where gut–liver axis disruption plays a pivotal role in driving hepatic injury and immune-mediated pathology
Dietary Zinc Deficiency and Repletion Modulate Metallothionein . . . Pair-fed control rats had elevated MT concentration in liver that was normalized by energy repletion There was a significant positive correlation between tissue Zn and MT concentrations in liver (r = 0 60, P = 0 0001), but not in small intestine
Differential role of metallothionein on Zn, Cd and Cu . . . - Springer Abstract To examine the role of metallothionein (MT) on heavy metal accumulation in hepatic cytosol of rats, this study was carried out to determine the relative Zn, Cd and Cu-binding capacities of MT in hepatic cytosol of Zn, Cd and Cu-injected rats, respectively
Metallothionein-Independent Zinc Protection from Alcoholic Liver Injury These results demonstrate that zinc, independent of MT, plays an important role in protection from alcoholic liver injury However, MT is required to maintain high levels of zinc in the liver, suggesting that the protective action of MT in the liver is likely mediated by zinc
Property of metallothionein as a Zn pool differs depending on the . . . Although the induction of hepatic MT by a wide range of stressors is a well-known phenomenon, little is known about the role of MT in stressful situations Since MT regulates Zn metabolism, we investigated the differences between affinities of MT for Zn in various stressful conditions in this study
Impact of zinc on hepatocellular carcinoma cell behavior and . . . Finally, Zn and MT1 (Metallothionein 1) levels were quantified in plasma from patients with HCC Results: Zn supplementation significantly modulated proliferation, invasion, and migration in HCC cell lines and induced apoptosis in a dose-dependent manner