Pathology Outlines - Serous tubal intraepithelial carcinoma 55 year old woman with synchronous papillary serous carcinoma of ovary and endometrium and STIC (Indian J Pathol Microbiol 2017;60:125) 56 year old woman with incidental STIC (Case Rep Obstet Gynecol 2015;2015:760429) 58 year old woman with retroperitoneal high grade serous carcinoma and STIC (Diagn Pathol 2019;14:17)
Pathology Outlines - p53 Differentiate serous tubal intraepithelial carcinoma (STIC) from reactive changes in epithelium of the fallopian tube or fimbriae, although serous tubal intraepithelial lesions may also have aberrant p53 phenotype and histologic differentiation is important (Int J Gynecol Pathol 2011;30:417, Int J Gynecol Pathol 2021;40:419)
Pathology Outlines - WHO classification Most high grade serous carcinomas of the ovary arise at the fimbriated end of the fallopian tube from a precursor lesion known as serous tubal intraepithelial carcinoma (STIC) (Pathology 2015;47:423, Mod Pathol 2015;28:1101) Undifferentiated carcinoma of the fallopian tube is no longer a separate category
Pathology Outlines - Adenocarcinoma in situ 30 year old woman with prior HSIL on Pap smear (Case of the Week #202) 30 year old woman with atypical glandular cells on Pap smear with subsequent diagnosis of stratified mucin producing intraepithelial lesion (SMILE) and HSIL on biopsy (Virol J 2019;16:76)
Pathology Outlines - High grade serous carcinoma Fallopian tubes - Serous carcinoma High stage with pelvic extension or positive peritoneal cytology To call primary in fallopian tube, should arise from mucosa (endosalpinx), have tubal histologic pattern, involve the lumen, uterus and ovaries must be normal or have foci of malignancy that resemble metastases or independent primaries; if tubal wall is involved, should detect a transition
Pathology Outlines - WHO classification Most high grade serous carcinomas of the ovary arise from the distal fimbria of the fallopian tube from a precursor lesion known as serous tubal intraepithelial carcinoma (STIC) (Pathology 2015;47:423, Mod Pathol 2015;28:1101) Low grade serous carcinomas of the ovary arise from benign or borderline serous neoplasms
WHAT’S NEW IN PATHOLOGY? - PathologyOutlines. com precursor lesion, STIC (serous tubal intraepi-thelial carcinoma), in the tubal fimbriae • New criteria for primary site assignment in HGSC include: - Fallopian tube: STIC present, or mucosal HGSC present, or part or all of the fallopian tube is inseparable from tubo-ovarian mass - Ovary: both fallopian tubes are separate from