Thyroid hormone receptor alpha - Wikipedia Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene [5][6][7]
Thyroid hormone receptor beta: Relevance in human health and diseases THRA gene encodes for three isoforms, namely THRα1, THRα2, and THRα3 Isoform THRα1 binds to T 3, whereas THRα2 and THRα3 cannot bind to T 3 and thus inhibit TH actions (Kim and Mohan, 2013) THRα1 is highly expressed in the heart, adipose tissues, brain, etc