All Roads Lead to TREM2: Gearing Up to Target This Receptor Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease Findings presented at the International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to
TREM2 - ALZFORUM Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor of the innate immune system expressed on microglia, macrophages, dendritic cells, and osteoclasts
TREM2: A Chill Pill for Neurons? | ALZFORUM TREM2 created quite the buzz at this year’s AD PD meeting, held April 1-5 in Vienna In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings from early phase trials of a fresh batch of agonists Juxtaposing this were presentations that unveiled a new modus operandi for
TREM2 R47H - ALZFORUM Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set Neurobiol Aging 2016 Jun;42:217 e7-217 e13 Epub 2016 Mar 21 PubMed Gonzalez Murcia JD, Schmutz C, Munger C, Perkes A, Gustin A, Peterson M, Ebbert MT, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Kauwe JS
TREM2 H157Y - ALZFORUM Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set Neurobiol Aging 2016 Jun;42:217 e7-217 e13 Epub 2016 Mar 21 PubMed
TREM2 - ALZFORUM Intergenic - TREM locus : Unknown Predicted to influence transcription factor binding; 6 percent increase in expression of TREM2 and TREML1 in temporal cortex Carrasquillo et al , 2017: c -5030G>C (rs7759295) AD : Unclear Pathogenicity: Substitution: Non-Coding : Upstream