Home Page: Journal of Biological Chemistry The Journal of Biological Chemistry (JBC) welcomes high-quality science that seeks to elucidate the molecular and cellular basis of biological processes Papers published in JBC can therefore fall under the umbrellas of not only biological chemistry, chemical biology, or biochemistry, but also allied disciplines such as biophysics, systems biology, RNA biology, immunology, microbiology
Structural and functional analyses of pyroglutamate-amyloid-β-specific . . . Alzheimer disease is associated with deposition of the amyloidogenic peptide Aβ in the brain Passive immunization using Aβ-specific antibodies has been demonstrated to reduce amyloid deposition both in vitro and in vivo Because N-terminally truncated pyroglutamate (pE)-modified Aβ species (AβpE3) exhibit enhanced aggregation potential and propensity to form toxic oligomers, they
SARS-CoV-2 infects cells after viral entry via clathrin-mediated . . . Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, so understanding its biology and infection mechanisms is critical to facing this major medical challenge SARS-CoV-2 is known to use its spike glycoprotein to interact with the cell surface as a first step in the infection process As for other coronaviruses, it is likely that SARS-CoV-2 next
Identification of a reciprocal negative feedback loop between tau . . . The posttranslational regulation of the neuronal proteome is critical for brain homeostasis but becomes dysregulated in the aged or diseased brain, in which abnormal posttranslational modifications (PTMs) are frequently observed While the full extent of modified substrates that comprise the “PTM-ome” are slowly emerging, how the upstream enzymes catalyzing these processes are regulated
Helicobacter pylori - Journal of Biological Chemistry Infection with the Gram-negative, microaerophilic bacterium Helicobacter pylori induces an inflammatory response and oxidative DNA damage in gastric epithelial cells that can lead to gastric cancer (GC) However, the underlying pathogenic mechanism is largely unclear Here, we report that the suppression of Nei-like DNA glycosylase 2 (NEIL2), a mammalian DNA glycosylase that specifically
Two distinct sites of client protein interaction with the chaperone . . . Integral membrane proteins are prone to aggregation and misfolding in aqueous environments and therefore require binding by molecular chaperones during their biogenesis Chloroplast signal recognition particle 43 (cpSRP43) is an ATP-independent chaperone required for the biogenesis of the most abundant class of membrane proteins, the light-harvesting chlorophyll a b-binding proteins (LHCPs
Hyaluronan Synthases - Journal of Biological Chemistry In 1934, Meyer and Palmer isolated a novel, highMr glycosaminoglycan from the vitreous of the eye (1) They showed that this substance contained a hexuronic acid, an amino sugar, and no sulfoesters and proposed the name hyaluronic acid (hyaluronan, HA),1 from the Greekhyaloid (vitreous) and uronic acid It took 20 years before Weissmann and Meyer (2) finally established the precise structure