Pathology Outlines - Lichen planus Dyskeratotic keratinocytes are frequently seen at the basal layer Dyskeratotic keratinocytes (so called Civatte bodies) are frequently seen at the basal layer Civatte bodies are PAS positive Eosinophils are uncommon in conventional cutaneous lichen planus Lichen planus may occur on mucosal surfaces such as the oral mucosa or genitalia
Pathology Outlines - Lichen planus Colloid (civatte) bodies in the epithelium or superficial lamina propria Thin band of eosinophilic material in the basement membrane Well defined, band-like zone of cellular infiltration consisting mainly of lymphocytes and confined to the superficial lamina propria Liquefactive degeneration in the basal cell layer (hydropic degeneration)
Pathology Outlines - Lichenoid esophagitis Microscopic similarities to lichenoid esophagitis pattern: numerous intraepithelial lymphocytes, superficial neutrophils, parakeratosis and Civatte bodies Desquamated and hyperpink parakeratosis Pseudohyphae and budding yeast: GMS positive (should always be performed when entertaining a diagnosis of lichenoid esophagitis pattern)
Pathology Outlines - Lymphocytic esophagitis Epithelial damage consists of dyskeratotic keratinocytes (Civatte bodies) and nonspecific changes such as intracellular edema (spongiosis) (Am J Surg Pathol 2022;46:e55, Am J Surg Pathol 2020;44:198) Depending on the underlying disease, the T cell population may differ
Pathology Outlines - Pemphigoid Interface mucositis with Civatte bodies Subepithelial band of lymphocytes Direct immunofluorescence shaggy fibrin deposition at basement membrane zone Linear IgA disease Rare immune mediated, subepithelial blistering disease Mainly on skin; oral lesions less common
Pathology Outlines - Chronic ulcerative stomatitis Epithelial atrophy with Civatte bodies Subepithelial band of lymphocytes Direct immunofluorescence shows shaggy fibrinogen deposition at the basement membrane zone (BMZ) or C3 at BMZ and IgM positive colloid bodies (Mod Pathol 2017;30:S54) Clinically, lesions often respond to corticosteroid therapy (Oral Maxillofac Surg Clin North Am 2023;35:189)
Pathology Outlines - Erythema dyschromicum perstans Lichenoid interface infiltrate with basal cell squamatization and Civatte bodies, eosinophils possible Macular mastocytosis: Mast cells and edema are seen in the dermis Lichen planus: Hyperkeratosis without parakeratosis Hypergranulosis Dense superficial dermal band of lymphocytes causing alteration along the dermoepidermal junction
Pathology Outlines - Malakoplakia Answer C is incorrect because Howell-Jolly bodies are spherical intracytoplasmic inclusions within red blood cells Answer E is incorrect because psammoma bodies are a round collection of calcium, a form of calcification that is mostly extracellular and much bigger than an intracellular inclusion Comment Here Reference: Malakoplakia
Interface dermatitis - Pathology Outlines Apoptosis of the basal keratinocytes occurs by an active budding process that involves single cells condensing and fragmenting into small bodies (Civatte colloid bodies) Colloid bodies in the papillary dermis appear to trap immunoglobulins nonspecifically, particularly IgM (Am J Dermatopathol 2002;24:130)