The paradigm of IL-23-independent production of IL-17F and IL-17A and . . . IL-17A and IL-17F are produced by cells of the innate and adaptative immune system and activate the production of inflammatory mediators such as tumor necrosis factor α (TNFα), IL-1β, IL-6, granulocyte colony-stimulating factor (G-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF)
The IL-17 Story The IL-17 Story: A - ucbcompass. com Protective immunity after epidermal Candida colonization requires both IL-17A and IL-17F Candida albicans CFUs in the skin of WT, Il17a − −, Il17f − −,and Il17af − − mice on Day 7 after inoculation
IL-17 in the Pathogenesis of Disease: Good intentions gone awry An independent study has verified that commensal-driven gut Th17 cells express IL-17, IL-22 and IL-10 and further identified that they are uniquely dependent on DC expression of the C-type lectin receptor Mincle, which induces IL-6 and IL-23 expression (31)
IL-17: Chronic Inflammation Autoimmune Risk with IL17A, IL17F Genetic variants that increase the body’s production of IL-17A are a risk factor for inflammatory bowel disease (IBD), psoriasis, rheumatoid arthritis, bronchitis severity, gastric cancer, and more
Functional Specialization of Interleukin-17 Family Members In addition, IL-17A is produced by intestinal Paneth cells (Takahashi et al , 2008), whereas IL-17F mRNA, but not IL-17A mRNA, is expressed in colonic epithelial cells (Ishigame et al , 2009), suggesting that IL-17A and IL-17F from nonlymphoid cells may also regulate immune responses
IL-17 Family - theinfolist. com Interleukin-17A is a protein that in humans is encoded by the ''IL17A'' gene In rodents, IL-17A used to be referred to as CTLA8, after the similarity with a viral gene () Function The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells