Diseases of complement dysregulation—an overview - PMC Although complement overactivation is common to all, cell surface alternative pathway dysregulation (aHUS), fluid phase alternative pathway dysregulation (C3G), or terminal pathway dysregulation (PNH) predominates resulting in the very different phenotypes seen in these diseases
Complement deficiencies | Immune Deficiency Foundation The list of potential complement-related health problems includes renal disease, vasculitis (blood vessel inflammation), and age-related macular degeneration A history of family members having the same presentation should increase the suspicion of an inherited complement deficiency
What Are the Diseases Caused Due to Defects in the Complement . . . - iCliniq The complement system has been considered a simple killing cascade aimed at the pathogens infecting the host However, it is an intricate immune surveillance pathway because it plays a role in homeostasis (a self-regulating process to maintain balance), inflammation , and defense against pathogens
Editorial: The Role of Complement in Health and Disease Therefore, complement plays key roles in (i) preventing the spread of infection to other cells and tissues, (ii) participating in the clearance of damaged cells and tissues, and (iii) preventing the development of chronic inflammation and or cancer
Roche | Roche in complement-mediated diseases The complement system is a part of the body’s immune system which acts as our first line of defence against infections ¹ When the complement system is not properly regulated, it can cause a wide range of diseases, known as complement-mediated diseases
Complement Deficiency - StatPearls - NCBI Bookshelf Complement deficiencies are primary immunodeficiencies that cause various clinical scenarios depending on the specific deficient complement protein This can include an increased risk of a wide range of infectious and local or systemic inflammatory and thrombotic conditions [2]
Complement in human disease: approved and up-and-coming therapeutics Increased understanding of complement biology has led to the identification of novel targets for drug development that, in combination with advances in drug discovery and development technologies, has resulted in a surge of interest in bringing new complement therapeutics into clinical use
Complement genetics, deficiencies, and disease associations Genetic deficiency of any early component of the classical pathway (C1q, C1r s, C2, C4, and C3) is associated with autoimmune diseases due to the failure of clearance of immune complexes (IC) and apoptotic materials, and the impairment of normal humoral response