Pathology Outlines - ASCUS (cytology) Atypical squamous cells of undetermined significance (ASCUS) refers to cellular changes that are suggestive, but not diagnostic of, low grade squamous intraepithelial lesion (LSIL)
Pathology Outlines - ASC-H (cytology) Atypical squamous cells - cannot exclude high grade squamous intraepithelial lesion (ASC-H) refers to cytologic changes that are suggestive of high grade squamous intraepithelial lesion (HSIL) but insufficient for a definitive interpretation
Pathology Outlines - Bethesda system ASCUS nuclei are enlarged by 2 to 3 times, have smooth to slightly irregular nuclear membranes, finely granular chromatin, inconspicuous nucleoli and questionable cytoplasmic cavitations
Pathology Outlines - Squamous dysplasia Squamous dysplasia is noninvasive neoplastic proliferation of the anal squamous epithelium with cytologic and architectural abnormalities; it is associated with human papillomavirus (HPV) infection
Pathology Outlines - LSIL (cytology) Which of the following is the correct interpretation of the cervical cytology shown above from a 32 year old woman? Atypical glandular cells, NOS Atypical squamous cells of undetermined significance (ASCUS) Benign reactive squamous cells High grade squamous intraepithelial lesion (HSIL) Low grade squamous intraepithelial lesion (LSIL)
Pathology Outlines - Atrophy May cause increased incidence of ASCUS in Pap smears of peri- and post-menopausal women (Cancer 2001;93:100) Associated with scanty smears (Cytopathology 1997;8:274), ASCUS in postmenopausal women (Diagn Cytopathol 2001;24:132) Changes may disappear after topical estrogen
Pathology Outlines - HSIL CIN II CIN III Precancerous squamous proliferative lesion with full thickness nuclear atypia and varying degrees of cytoplasmic maturation; driven by high risk HPV subtypes
Pathology Outlines - Cervix Comprehensive resource on cervical pathology including chronic cervicitis, HPV-associated squamous cell carcinoma, adenoid basal carcinoma, and related diagnostic insights
Pathology Outlines - Cytopathology Bethesda system: Bethesda system ASC-H ASCUS atypical glandular cells LSIL HSIL Effusion cytology: International system for reporting serous fluid cytopathology IHC panels Kidney: WHO reporting system for kidney cytopathology (pending) Liver: WHO reporting system for liver cytopathology (pending)
Pathology Outlines - AUS Bethesda category III, atypia of undetermined significance (AUS) is used for cases with a minor degree of atypia, primarily cytologic or architectural in nature, insufficient to qualify for either of the indeterminate categories and higher