What are the functions of disulphide bonds? - Biology Stack Exchange Disulphide bonds occur in proteins, not amino acids, although they involve a covalent bond between two amino acids (both cysteine) The received wisdom is that disulphides are used as extra stabilisation of the structure of proteins which are secreted, or which have an extracellular domain
How do disulphide bonds in hair cause curling? - Biology Stack Exchange These protofibrils are made up of 4 keratin chains which are essentially twisted together and connected by disulphide bonds and hydrogen bonds While hydrogen bonds are easily broken, the disulphide bonds are not In curled hair, the macrofibril isn't symmetrical but I am unsure as to how this, or what other effects, actually lead to the curling
What is the significance of cysteine in a protein sequence? Disulphide bonds play important roles in protein folding and stability (60 kcal mol compared to around 1 and 5 kcal mol for a hydrogen bond depeneding on the environment) Notably though, cysteine disulphide bonds are usually only used in extracellular secreted proteins, as they are unstable in the cytoplasm As an example, take the structure 2ksk
Procedure of diagonal electrophoresis - Biology Stack Exchange I am learning protein sequencing and it seems that diagonal electrophoresis is a common method in the identification of disulphide bonds (S-S) exist between polypeptides in a protein Questions: A
How does protein denaturation work? - Biology Stack Exchange The unfolded protein can suffer irreversible changes (aggregation, disulphide exchange, proteolysis, irreversible subunit dissociation, chemical degradation, etc ), so the denaturation of the protein can be reversible or irreversible
What makes the cytoplasm a reducing environment? It is known that the cytoplasm is a "reducing" environment, where disulfide bonds cannot form (will soon be reduced to 2 cysteines) [I'm not putting a link as this is a fact in many biology textboo
Molecularly, why can you straighten or perm hair? I'm aware that hair can be curly because of the disulfide bond interactions in between cysteine amino acids in alpha-keratin filaments However, I'm curious as to the biochemistry involved in
Dimerization of Immunoglobulin G - Biology Stack Exchange I would like to know the specific determinants for formation of IgG dimers My understanding is the stem of the antibody is a homodimer of two heavy chains, covalently bonded through two disulfide