Penicillins - Action, Indications, Effects, Nursing Considerations Administration: The route of administration is determined by the stability of the drug to the gastric environment and the severity of the infection The combination of ampicillin with sulbactam; ticarcillin with clavulanic acid; piperacillin with tazobactam; and nafcillin and oxacillin must be administered IV or IM
Ampicillin and amoxicillin: Mechanism of Drug Action . . . - ChemicalBook Ampicillin and amoxicillin have actions similar to penicillin G (Benzylpenicillin (Penicillin G)) The differences in their antibacterial spectrum, compared with penicillin G, can be explained by their greater ability to penetrate the outer membrane of the cell wall of some Gram-negative bacilli
3. 5 Penicillins – Nursing Pharmacology Penicillins may be administered orally, IV, or intramuscularly Mechanism of Action: Penicillins are bactericidal and kill bacteria by interfering with the synthesis of proteins needed in their cellular walls [2] When the bacterial cell wall is impaired, the cell is rapidly broken down and destroyed
3. 5 Penicillin – Nursing Pharmacology-2e UWEC Penicillins may be administered orally, IV, or intramuscularly Nursing Considerations: In addition to general antimicrobial administration considerations, patients receiving penicillins must be monitored for signs of superinfections such as C-diff or yeast infections There is also a cross-sensitivity for patients allergic to cephalosporins
Antibiotics - Penicillins: Nursing pharmacology - Osmosis On the other hand, broad spectrum penicillins include amoxicillin, which is given orally, and ampicillin, which is administered orally, intramuscularly or intravenously They’re effective against a wide variety of gram negative bacteria, so they’re useful to treat respiratory, gastrointestinal, genitourinary, and skin infections
3. 6 Penicillins – Fundamentals of Nursing Pharmacology – 1st Canadian . . . Penicillins may be administered orally, IV, or intramuscularly Penicillins are bactericidal and kill bacteria by interfering with the synthesis of proteins needed in their cellular walls When the bacterial cell wall is impaired, the cell is rapidly broken down and destroyed
Penicillin: classification, mode of action and penicillin resistance Ampicillin and Amoxycillin are used against Enterobactericeae family but not against Klebsiella and Pseudomonas These antibiotics are relatively stable to gastric acid and are suitable for oral administration Examples: Penicillin V (Phenoxy methyl penicillin) 1 Inhibition of cell wall synthesis by blocking transpeptidation:
Pharmacology of Penicillins Oral Bioavailability: Penicillin V, amoxicillin, and dicloxacillin are adequately absorbed from the GI tract; penicillin G is unstable in acidic gastric pH and typically given parenterally Food can reduce absorption of some penicillins (except amoxicillin), so they are often taken on an empty stomach for optimal levels
Antibiotics - Cerritos College Penicillins: The penicillins are bactericidal and act by interfering with bacterial cell wall synthesis They diffuse well into body tissues and fluids, but penetration into the cerebrospinal fluid is poor except when the meninges are inflamed They are excreted in the urine in therapeutic concentrations Pharmacokinetics
STRUCTURE OF COMMONLY USED PENICILLINS - Columbia University Penicillins bind to a number of receptor proteins, transpeptidases and carboxypeptidases called penicillin binding proteins (PBPs) Different microorganisms vary in the affinity of their PBPs for penicillin