Propofol-Related Infusion Syndrome: A Clinical Review - PMC Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients
Propofol infusion syndrome - Wikipedia Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol
PRIS - Home The Power Reactor Information System (PRIS), developed and maintained by the IAEA for over five decades, is a comprehensive database focusing on nuclear power plants worldwide
Propofol-Related Infusion Syndrome (PRIS) Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism
Propofol Infusion Syndrome? – ResusNation Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition that was first reported in children in 1990 It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest
Propofol Related Infusion Syndrome - DFW Anesthesia Professionals Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly
Propofol Related Infusion Syndrome (PRIS) - First10EM Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease
Propofol Infusion Syndrome: A Rare Complication From a Common . . . Propofol infusion syndrome (PRIS) is a multifactorial condition that, upon propofol administration, can interrupt critical cellular processes This can lead to cellular damage that translates as multi-organ system failure that has the potential to be life-threatening
Propofol infusion syndrome - WikEM Background PRIS = propofol infusion syndrome Refractory bradycardia and cardiovascular collapse Poorly understood mechanism Risk factors High doses of (> 4mg kg hr or 67 mcg kg min) Long duration (> 48 hrs) Younger age (PRIS first recognized in pediatric population) Critical illness Malnutrition Liver disease Carnitine deficiency Mitochondrial