Should we treat pyrexia? And how do we do it? - Critical Care The concept of pyrexia as a protective physiological response to aid in host defence has been challenged with the awareness of the severe metabolic stress induced by pyrexia The host response to pyrexia varies, however, according to the disease profile and severity and, as such, the management of pyrexia should differ; for example, temperature control is safe and effective in septic shock but
Pyrexia: aetiology in the ICU | Critical Care | Full Text - BioMed Central Most episodes of pyrexia are due to infections, but incidence estimates of infectious and noninfectious aetiologies are limited by studies with small sample size and inconsistent reporting of noninfectious aetiologies Pyrexia commonly triggers a full septic work-up, but on its own is a poor predictor of culture-positivity
The pathophysiological basis and consequences of fever The teleological benefit of pyrexia following brain injury is uncertain Endocrine fever Thyroid hormones are essential for regulation of energy metabolism Hyperthyroidism is associated with hyperthermia; patients with thyroid storm have an average body temperature of 38 0 °C; temperatures above 41 °C have been reported The mechanism of
Pyrexia: aetiology in the ICU - BioMed Central noninfectious pyrexia, is more commonly observed in patients with hyperthermia Most episodes of pyrexia are due to infections, but incidence estimates of infectious and noninfectious aetiologies are limited by studies with small sample size and inconsistent reporting of noninfectious aetiologies Pyrexia commonly triggers a full septic work-up,
The pathophysiological basis and consequences of fever - BioMed Central meaning simply ‘heat’, and pyrexia comes from the Greek ‘pyr’, meaning fire or fever Some sources use the terms interchangeably, whereas others preserve ‘fever’ to mean a raised temperature caused by the action of thermoregula-tory pyrogens on the hypothalamus; for instance, in sepsis and inflammatory conditions [3]
Fever and hypothermia represent two populations of sepsis patients and . . . Background Fever and hypothermia have been observed in septic patients Their influence on prognosis is subject to ongoing debates Methods We did a secondary analysis of a large clinical dataset from a quality improvement trial A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors
Should we treat pyrexia? And how do we do it? The cost of pyrexia should be considered in several ways Pyrexia has a metabolic cost such that cooling fe-brile ICU patients will reduce oxygen consumption by 10 % per °C [6] Small studies in sedated patients dem-onstrated a significant reduction in VO 2 (the rate of oxy-gen consumption) and VCO 2 (the rate of carbon dioxide
Targeted temperature control following traumatic brain injury: ESICM . . . Aims and scope The aim of this panel was to develop consensus recommendations on targeted temperature control (TTC) in patients with severe traumatic brain injury (TBI) and in patients with moderate TBI who deteriorate and require admission to the intensive care unit for intracranial pressure (ICP) management Methods A group of 18 international neuro-intensive care experts in the acute
Fever in sepsis: is it cool to be hot? - Critical Care Changes in body temperature are a characteristic feature of sepsis The study by Kushimoto and colleagues in a recent issue of Critical Care demonstrates that hypothermia is a very important manifestation of infection associated with very high mortality Combined with recent data suggesting that febrile patients with infections have the lowest mortality risk, the study raises the question of
Body temperature affects cerebral hemodynamics in acutely brain injured . . . Introduction Temperature changes are common in patients in a neurosurgical intensive care unit (NICU): fever is frequent among severe cases and hypothermia is used after cardiac arrest and is currently being tested in clinical trials to lower intracranial pressure (ICP) This study investigated cerebral hemodynamics when body temperature varies in acute brain injured patients Methods We