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Lipopolysaccharides, BioXtra, suitable for cell culture Sigma Aldrich Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs)