Emerging treatments for itch in atopic dermatitis: A review Atopic dermatitis is a chronic inflammatory skin condition with a high prevalence that is increasing The most universal symptom in patients with atopic dermatitis is pruritus; it is often the most troublesome symptom New insights on the mechanism of itch in patients with eczema have been elucidated, involving cross-talk between neural and immune systems, which have advanced our treatments
Atopic dermatitis: a brief review of recent advances in its management Abstract Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by recurrent eczematous lesions and intense itching The disorder affects people of all ages and ethnicities, has a substantial psychosocial impact on patients and relatives, and is the leading cause of the global burden of skin diseases
Atopic Dermatitis Itch: Scratching for an Explanation Chronic itch is a defining symptom of atopic dermatitis (AD) and leads to significant morbidity The pathophysiology of pruritus in AD involves various mediators and complex neuroimmune interactions Other factors such as disruption of the skin barrier, sweat, and the skin microbiome may also exacerbate itch in these patients
Real-world evidence on the benefits of optimal itch relief and skin . . . Background: In atopic dermatitis (AD), the real-world impact of achieving itch and skin lesion treatment targets compared to partial improvement remains unclear Objective: We assessed the relationship between itch relief (reduction in Worst Itch Numeric Rating Scale [WI-NRS]) and skin clearance (Investigator Global Assessment [IGA] 0 1) with other patient-reported outcomes
Atopic Dermatitis Itch: Scratching for an Explanation exciting future research directions to better understand atopic pruritus in darker skin types Keywords: Atopic Dermatitis, Itch, Pruritus Journal of Investigative Dermatology (2024) 144, 978e988; doi:10 1016 j jid 2023 10 048 INTRODUCTION Chronic itch is a defining symptom of atopic dermatitis (AD) and leads to significant morbidity
The Complex Science Behind Itch in Atopic Dermatitis 14 Legat FJ Itch in Atopic Dermatitis – What Is New? Front Med (Lausanne) 2021;8:644760 15 Misery L, Belloni Fortina A, El Hachem M, et al A position paper on the management of itch and pain in atopic dermatitis from the International Society of Atopic Dermatitis (ISAD) Oriented Patient-Education Network in Dermatology (OPENED) task force
Current Clinical Options for the Management of Itch in Atopic . . . A systematic review of second-generation antihistamines, such as fexofenadine, cetirizine, or loratadine, did not find any evidence that these agents are effective in improving atopic itch 60 In a trial including 795 children with AD, daily cetirizine was found to be effective in reducing the Scoring of Atopic Dermatitis (SCORAD) score, when
Peripheral itch sensitization in atopic dermatitis - ScienceDirect Itch-scratch spiral and key points of therapeutic intervention in atopic dermatitis Itching easily occurs when dry skin is subjected to itch stimuli Scratching behavior breaks down the skin barrier, causing the release of various itch mediators, sensitizers, and proinflammatory substances The challenge of basic itch research Acta Derm