Terminal deoxynucleotidyl transferase - Wikipedia Terminal deoxynucleotidyl transferase (TdT), also known as DNA nucleotidylexotransferase (DNTT) or terminal transferase, is a specialized DNA polymerase expressed in immature, pre-B, pre-T lymphoid cells, and acute lymphoblastic leukemia lymphoma cells
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Terminal Deoxynucleotidyl Transferase: The Story of a Misguided DNA . . . Our discussion begins by examining the biological role of TdT and how synthesizing DNA without using a templating strand is important for V (D)J recombination Attention will then focus on understanding the molecular mechanism by which TdT performs template-independent polymerization
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Terminal Deoxynucleotidyl Transferase - Stanford SSI Wiki TdT uses divalent cations as catalysts to extend DNA, and the efficiency of the reaction is affected by the type of cation used Zinc and magnesium cations work best for extension, with magnesium causing TdT to prefer dGTP and dATP