Stevens Johnson Syndrome Toxic Epidermal Necrolysis. SJS TEN Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are now believed to be variants of the same condition, distinct from erythema multiforme SJS TEN is a rare, acute , serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss
SJS-TEN images - DermNet SJS images, TEN images, Stevens Johnson syndrome images, Toxic epidermal necrolysis images
Drug hypersensitivity syndrome. DRESS - DermNet It may have overlapping features with Stevens–Johnson syndrome toxic epidermal necrolysis (SJS TEN) and acute generalised exanthematous pustulosis (AGEP) Who gets drug hypersensitivity syndrome? Drug hypersensitivity syndrome is relatively rare It mainly affects adults and is equal in incidence in males and females
Severe cutaneous adverse reaction - DermNet SJS TEN often presents with a few days of prodromal illness with fever (> 39 C), malaise, cough, a blocked or runny nose, sore throat and sore eyes The rash then appears and extends over 5–7 days It usually starts on the face, chest, and the proximal limbs, and then spreads widely
Erythema multiforme: histological features and mechanisms - DermNet Systemic symptoms such as fever and malaise, are absent or mild in EM but are prominent in SJS TEN, especially in the prodromal period Fever, when present in EM, is mild ( 38 5 C) compared to high fevers with SJS TEN Patients with SJS TEN are systemically ill Outcome and prognosis – virtually all patients with EM recover with no sequelae
Stevens Johnson syndrome toxic epidermal necrolysis: nursing management Stevens Johnson syndrome toxic epidermal necrolysis (SJS TEN) is a very severe and acute skin disease, almost always caused by a drug SJS TEN is characterised by an extensive necrosis and detachment of the epidermis, which involves skin and mucosal surfaces (genitals, eyes, and mouth)
Nikolskys sign - DermNet Using Nikolsky’s original definition strictly, his eponymous sign is the physical splitting of the epidermis creating an erosion (partial loss of the epidermis) following the application of a shearing force to the surface of the skin seen in pemphigus foliaceus However, with time the use of the sign has broadened to include other intraepidermal disorders including pemphigus vulgaris and it
Dermatological emergencies. Toxic epidermal necrolysis Erythema is followed by extensive full thickness cutaneous and mucosal necrosis and denudation within 2 or 3 days Similar symptoms and signs involving less than 10% of the body surface are classified as Stevens-Johnson syndrome (SJS); if 10-30% of body surface area is affected it is classified as T E N SJS overlap
Target and targetoid lesions - DermNet In Stevens-Johnson syndrome toxic epidermal necrolysis (SJS TEN), they are flat (macular) What are targetoid lesions? Targetoid lesions have concentric zones and look similar to target lesions but are not due to erythema multiforme They may evolve over a different time frame Several skin conditions cause targetoid lesions Melanocytic naevus
Adverse cutaneous reactions to psychotropic drugs - DermNet Stevens–Johnson syndrome toxic epidermal necrolysis (SJS TEN) is a severe, life-threatening illness with blistering of the mouth and other mucous membranes and widespread macular rash, with detachment of the epidermis from the dermis Psychotropic medications like alprazolam, duloxetine, sertraline and anticonvulsant medications can cause SJS