B-cell activating factor - Wikipedia As an immunostimulant, BAFF (BLyS, TALL-1) is necessary for maintaining normal immunity Inadequate level of BAFF will fail to activate B cells to produce enough immunoglobulin and will lead to immunodeficiency
B cell activating factor (BAFF): Structure, functions . . . - PubMed The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion BAFF expression is closely linked with autoimmunity and is enhanced by genetic alterations and viral infections
B cell activating factor (BAFF): Structure, functions, autoimmunity and . . . Belimumab, an anti-BAFF antibody, is the only biologic agent so far approved for SLE therapy The B cell activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a B cell survival factor which supports autoreactive B cells and prevents their deletion
BAFF signaling in health and disease - PubMed BAFF is a critical cytokine supporting the survival of mature naïve B cells, acting through the BAFFR receptor Recent studies show that BAFF and BAFFR are also required for the survival of memory B cells, autoimmune B cells as well as malignant chronic lymphocytic leukaemia (CLL) cells
BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases . . . It binds to three receptors: BAFFR, TACI, and BCMA that are differentially expressed by B cell subsets BAFFR is early expressed in circulating B cells and provides key signals for further maturation Here, we report that highly regulated BAFFR processing events modulate BAFF responses