Pentamer - Wikipedia In microbiology, a pentamer is one of the proteins that compose the polyhedral protein shell that encloses the bacterial micro-compartments known as carboxysomes In immunology, an MHC pentamer is a reagent used to detect antigen-specific CD8+ T cells
Structure and Function of Immunoglobulins - PMC The pentamer also contains a polypeptide chain, the J-chain, which is bound to two of the monomers by means of a disulfide bond The J-chain facilitates secretion at mucosal surfaces (see below)
13. 1B: Antibody Structure - Biology LibreTexts Individual "Y"-shaped antibody molecules are called monomers and can bind to two identical epitopes Antibodies of the classes IgG, IgD, and IgE are monomers Two classes of antibodies are more complex IgM (see Figure 13 1B 10 13 1 B 10) is a pentamer, consisting of 5 "Y"-like molecules connected at their Fc portions by a "J" or joining chain
Structural insights into immunoglobulin M | Science We report a cryo–electron microscopy structure of the Fc region of human IgM in complex with the J-chain and pIgR ectodomain The IgM-Fc pentamer is formed asymmetrically, resembling a hexagon with a missing triangle The tailpieces of IgM-Fc pack into an amyloid-like structure to stabilize the pentamer
Immunoglobulin M (IgM) – Properties, Structure and Functions Immunoglobulin M is the third most common serum Ig and exists in two forms: a pentamer comprising approximately 10% of normal human serum Ig content and a membrane-bound monomer expressed on the surface of B lymphocytes for antigen recognition
Immunoglobulin M (IgM)- Structure and Functions - Microbe Notes Serum IgM exists as a pentamer and comprises approximately 10% of normal human serum Ig content It is the third most abundant human immunoglobulin It predominates in primary immune responses to most antigens and is the most efficient complement fixing immunoglobulin
13. 1C: The 5 Classes (Isotypes) of Human Antibodies IgM makes up approximately 13% of the serum antibodies, is the first antibody produced during an immune response, is found mainly in the blood, and is a pentamer with 10 Fab sites