Protamine sulfate - Wikipedia Protamine sulfate is a medication that is used to reverse the effects of heparin [2] It is specifically used in heparin overdose, in low molecular weight heparin overdose, and to reverse the effects of heparin during delivery and heart surgery [2] [3] It is given by injection into a vein [2] The onset of effects is typically within five
Protamine - StatPearls - NCBI Bookshelf Protamine is a medication used to reverse and neutralize the anticoagulant effects of heparin Protamine is the specific antagonist that neutralizes heparin-induced anticoagulation
Protamine (Protamines): Side Effects, Uses, Dosage . . . - RxList Protamine Sulfate (protamines) is a heparin antagonist and a weak anticoagulant indicated in the treatment of heparin (a drug used to treat and prevent blood clots) overdose What Are Side Effects of Protamine? Common side effects of Protamine Sulfate include: temporary flushing and a feeling of warmth
Protamine • LITFL • CCC Pharmacology Protamine: neutralization of heparin Strongly basic protamine + strongly acid heparin -> forms stable salt -> removed by reticuloendothelial system Skip to content
What’s fishy about protamine? Clinical use, adverse reactions, and . . . Protamine, a highly basic protein isolated from salmon sperm, is the only clinically available agent to reverse the anticoagulation of unfractionated heparin Following intravenous administration, protamine binds to heparin in a nonspecific electrostatic interaction to reverse its anticoagulant effects
Protamine Sulfate Injection: Package Insert Prescribing Info - Drugs. com Protamine Sulfate Injection, USP is a sterile, isotonic solution of protamine sulfate It acts as a heparin antagonist It is also a weak anticoagulant Each mL contains: Protamine sulfate 10 mg; sodium chloride 9 mg; Water for Injection q s Sulfuric acid and or dibasic sodium phosphate (heptahydrate) may have been added for pH adjustment