Targeting CREB for Cancer Therapy: Friend or Foe - PMC These results suggest that CREB is a suitable transcription factor for drug targeting and therefore targeting CREB could represent a novel strategy for cancer therapy
Targeting CREB in Cancer Therapy: A Key Candidate or One of Many . . . - MDPI Overexpression and hyperactivation of CREB are frequently observed in cancer, whereas genetic and pharmacological CREB downregulation affects proliferation and apoptosis Notably, the present review is designed to investigate the feasibility of targeting CREB in cancer therapy
CREB Signaling Mechanisms in Cancer Pathophysiology - Nature A comprehensive review has mapped the multi-layered regulation of CREB family members, detailing how alternative splicing, post-translational modifications, non-coding RNAs and epigenetic marks
Role of cAMP–PKA–CREB Signaling Pathway in Cancer - Springer This chapter emphasizes the crucial involvement of cAMP–PKA–CREB signaling in various types of cancers and the process of tumorigenesis Additionally, potential approaches to target this pathway for cancer therapy are explored and discussed
Targeting CREB in Cancer Therapy: A Key Candidate or One of Many? An . . . Overexpression and hyperactivation of CREB are frequently observed in cancer, whereas genetic and pharmacological CREB downregulation affects proliferation and apoptosis Notably, the present review is designed to investigate the feasibility of targeting CREB in cancer therapy
Short Title: Cancer cell intrinsic CREB and immune . . . - bioRxiv Overall, these findings position CREB as a pivotal node linking cancer cell autonomous oncogenic signaling to macrophage driven immune suppression, offering rationale for therapeutic targeting of the CREB-LIF axis to restore anti-tumor immunity in PDAC