APOE Alleles and Diet in Brain Aging and Alzheimer’s Disease The Response of APOE4 Carriers to Dietary and Lifestyle Interventions We have identified important factors that can inform the choice of future dietary and pharmacological interventions designed to mitigate the aging effects of APOE4 The first is the co-regulation of APOE-TOMM40-APOC1 locus by PPARγ
Interaction between APOE4 status and lifestyle on brain and cognitive . . . interplay between APOE4 genotype and various lifestyle factors (i e , cognitive activity, adherence to the Mediterranean diet and physical activity) on multimodal neuroimaging markers and cognition in cognitively unimpaired older adults
APOE4, lifestyle factors, and cognitive decline: We examined the association of adher-ence to lifestyle factors with cognitive decline separately in those with and without APOE4 using a linear mixed effect model adjusted for age, sex, education, race, car-diovascular disease, time, and their interactions with time
APOE Genotype Effect on Cognitive Change During a Lifestyle Intervention The extended 7-year FINGER follow-up will provide additional data for investigating whether the multidomain lifestyle intervention is effective for preventing dementia, whether this effect is modified by APOE genotype, and whether the cognitive change pattern observed among ε4 carriers persists for a longer period
Precision Nutrition for Alzheimer’s Prevention in ApoE4 Carriers - MDPI However, the authors report the integration between basic scientific mechanisms and human observational studies to create a rationale for a useful approach in adopting a lifestyle and nutrition plan aiming at AD’s risk reduction in APOE4 patients
The effect of the APOE4 genotype on physiological and cognitive health . . . Randomised controlled trials have investigated whether the strongest genetic risk factor for Alzheimer’s disease, APOE4, impacts the effectiveness of exercise on health Systematic reviews are yet to evaluate the effect of exercise on physical and cognitive outcomes in APOE genotyped participants
APOE Genotype and Alzheimer’s Disease: The Influence of Lifestyle and . . . In this Review, we aim to discuss available evidence of the prominent APOE genotype−environment interactions in regard to cognitive decline with a focus on AD, providing an overview of the current landscape in this field and suggesting future directions
Impact of the Apolipoprotein E ε4 Allele on the Relationship Between . . . In this study, we prospectively examined the role of the APOE*E4 allele in the relationship between adherence to a healthy lifestyle and cognitive decline in a population-based study, the Chicago Health and Aging Project (CHAP)
Effect of physical exercise on cognitive function in older adults . . . This systematic review and meta-analysis study the role of physical exercise as a potentially preventive intervention against cognitive decline in older adults’ ApoE4 carries and noncarriers, by evaluating the quality of available evidence