Blood volume and albumin transudation in critically ill COVID-19 . . . Albumin transudation rate is presented as a numeric value with 0 0025 (0 25% min exiting the circulation) serving as the normal reference threshold We report absolute variation (values at admission minus value at day of measurement for each case), and day-indexed values, calculated by dividing the absolute variation by the number of days in
Blood volume and albumin transudation in critically ill COVID-19 patients the ATR Albumin transudation rate is presented as a numeric value with 0 0025 (0 25% min exiting the cir-culation) serving as the normal reference threshold We report absolute variation (values at admission minus value at day of measurement for each case), and day-indexed values, calculated by dividing the absolute vari-
Individualized PEEP can improve both pulmonary hemodynamics and lung . . . Rationale There are several approaches to select the optimal positive end-expiratory pressure (PEEP), resulting in different PEEP levels The impact of different PEEP settings may extend beyond respiratory mechanics, affecting pulmonary hemodynamics Objectives To compare PEEP levels obtained with three titration strategies—(i) highest respiratory system compliance (CRS), (ii) electrical
Gravitational distribution of regional opening and closing pressures . . . Background The physiological behavior of lungs affected by the acute respiratory distress syndrome (ARDS) differs between inspiration and expiration and presents heterogeneous gravity-dependent distribution This phenomenon, highlighted by the different distribution of opening closing pressure and by the hysteresis of the pressure–volume curve, can be studied by CT scan, but the technique
Lung distribution of gas and blood volume in critically ill COVID-19 . . . Background Critically ill COVID-19 patients have pathophysiological lung features characterized by perfusion abnormalities However, to date no study has evaluated whether the changes in the distribution of pulmonary gas and blood volume are associated with the severity of gas-exchange impairment and the type of respiratory support (non-invasive versus invasive) in patients with severe COVID
Fluid balance and colloid osmotic pressure in acute respiratory failure . . . Available evidence suggests that both hydrostatic and osmotic forces are important in the development of acute respiratory distress syndrome (ARDS) or, more broadly, acute lung injury (ALI) More than 80% of ARDS patients in a large-scale randomized controlled trial (RCT) exhibited, at least intermittently, pulmonary artery wedge pressures (PAWP) above 18 mmHg Retrospective analyses have
Detection of hypovolemia by non-invasive hemodynamic monitoring during . . . Background Fluid loading with crystalloids is the conventional treatment of major hemorrhage but might tend to create fluid overload We studied hemodynamic profiles of fluid replacement therapies during major surgical hemorrhage and compared the ability of pulse pressure variation (PPV), plethysmographic variation index (PVI), cardiac output (CO) and Guyton´s approach to detect hypovolemia
COVID-19 UPDATES | Critical Care 2020 Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus Arif Hussain, Gabriele Via, Lawrence Melniker, et al