Paradoxical increase in lumen size during progression of coronary . . . Our study demonstrates that during relatively early stages of coronary artery disease (non-complex plaques with angiographic diameter stenosis <50%) there is a paradoxical increase in lumen area with progression of disease
Factors Affecting Artery Size and Blood Flow - Yale School of Medicine This results in poor blood flow and ischemia, which causes pain and ultimately tissue damage, and, in some cases, death Yale researchers recently published a paper in Nature Cardiovascular Research investigating pathways that regulate vessels that remodel to become larger (or outward remodeling)
Arterial Remodeling | Circulation - AHA ASA Journals Arterial remodeling, not plaque size, has been identified as the primary determinant of lumen size in the presence of stable lesions Similarly, luminal stenosis in transplant vasculopathy and with restenosis after angioplasty occur mainly because of inward remodeling rather than plaque growth
Variations in atherosclerosis and remodeling patterns in aorta and . . . In our patient population, the lumen size increased in the abdominal aorta but did not change in carotid artery and thoracic aorta Thus, different vascular locations exhibited varying progression regression of atherosclerosis and remodeling
Remodeling is a more important determinant of lumen size than atheroma . . . Change in plaque area correlated well with change in total vessel area (R = 0 64, P < 0001) but only weakly with change in lumen area (r = 0 14, P = 039) Although LMCA length correlated negatively with baseline lumen area and total vessel area, it did not correlate with their changes over time
Section Three: Chapter 16: Blood Vessels: Resistance and Pressure vessels have a lumen, the central area through which blood flows In general blood vessels transport blood in this v ssel order: Arteries, arterio s, capillaries, venules and veins This leads back to the heart There are some important exceptions (e g , portal systems) but most commonl
Differential enlargement of artery segments in response to enlarging . . . In the proximal LAD artery, the most severely diseased arteries increased in size 62% but lumen area decreased 25% In the midportion of the LAD artery, plaque area was 10 times greater in the most diseased arteries, but lumen area remained normal because of an 80% increase in artery size
Paradoxical increase in lumen size during progression of coronary . . . Our in vivo serial IVUS observations demonstrate that during active progression of coronary atherosclerosis the vessel lumen can actually become larger Of equal importance, the current study shows that regression can occur without any change in lumen area
Lumen diameter of normal human coronary arteries. Influence of age, sex . . . Precise knowledge of the expected "normal" lumen diameter at a given coronary anatomic location is a first step toward developing a quantitative estimate of coronary disease severity that could be more useful than the traditional "percent stenosis "