Variant of Uncertain Significance (VUS) - National Human Genome . . . When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
What to do if your genetic test finds a variant of uncertain . . . But sometimes, you might not get a clear “yes” or “no ” You might just get a “maybe ” “That’s what you’ll hear if you have a variant of uncertain significance, or VUS for short,” says Sara Wofford, a genetic counselor at MD Anderson The Woodlands
The challenge of genetic variants of uncertain clinical significance: A . . . Take Home Points Gene variants of uncertain clinical significance (VUS) are a frequent outcome of genomic testing VUS complicate clinical decision-making, and can result in costs to the health care system, worry, and unnecessary clinical procedures
Assessing a Variant of Uncertain Significance (VUS) Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation
What Is a VUS? Variants of Unknown Significance in Genetic Testing and . . . What to do if your genetic test results include a VUS If you have one or more VUSs in your genetic test results, the most important next step is to talk with a neuromuscular specialist or genetic counselor They can look at the whole picture and decide what, if anything, to do next
GENERAL GUIDELINES VUS RESULTS GUIDE - Labcorp ed to test family members for a VUS In some cases, the genetic testing report will indicate that testing family mem tives have their own genetic makeup Although these results did not find a significant genetic change, family members can discuss their own potential health and or reproductive risks and the option of genetic testing
VUS Variant of Uncertain Significance for cancer patients - MC1185-82 Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known
Considerations for Variants of Uncertain Significance (VUS) Variants with insufficient or conflicting evidence supporting disease association, which cannot be classified as ‘pathogenic likely pathogenic’ (disease-associated), nor as ‘benign likely benign’ (not disease-associated), are called Variants of Uncertain Significance (VUS)