Variant of Uncertain Significance (VUS) When analysis of a patient’s genome identifies a variant, but it is unclear whether that variant is actually connected to a health condition, the finding is called a variant of uncertain significance (abbreviated VUS)
What to do if your genetic test finds a variant of uncertain . . . But sometimes, you might not get a clear “yes” or “no ” You might just get a “maybe ” “That’s what you’ll hear if you have a variant of uncertain significance, or VUS for short,” says Sara Wofford, a genetic counselor at MD Anderson The Woodlands
VUS Variant of Uncertain Significance for cancer patients - MC1185-82 Some people, like you, have a Variant of Uncertain Significance (VUS) which is a genetic change that the laboratory cannot interpret VUS cannot be categorized as potentially disease causing or harmless because the meaning of this type of genetic change is not yet known
What Is a VUS? Variants of Unknown Significance in Genetic Testing and . . . What to do if your genetic test results include a VUS If you have one or more VUSs in your genetic test results, the most important next step is to talk with a neuromuscular specialist or genetic counselor They can look at the whole picture and decide what, if anything, to do next
Assessing a Variant of Uncertain Significance (VUS) Figuring out if a VUS falls more on the benign or pathogenic side is the first step in determining how to discuss it with a patient and whether to pursue further investigation
Rates and Classification of Variants of Uncertain Significance in . . . In general, VUS rates were highest in individuals who were not of European White descent (eg, Asian, Black, Hispanic, Native American, Pacific Islander, and Sephardic Jewish) and in genes associated with disorders of incomplete penetrance
Variant of Uncertain Significance (VUS): meaning, causes and . . . A Variant of Uncertain Significance (VUS) is a genetic variant identified through genetic testing that cannot be clearly classified as either benign (not disease-causing) or pathogenic (disease-causing) based on the available evidence