effects of voluntary exercise on oocyte quality in a diet-induced obese . . . Here we show that in a mouse model of an exercise, intervention can improve lipid metabolism in germinal vesicle (GV) stage oocytes Oocytes significantly increased activity and transcription of the β-oxidation enzyme hydroxyacyl-coenzyme A dehydrogenase in response to exercise training only if the mice had been fed a high-fat diet (HFD)
The effects of voluntary exercise on oocyte quality in a diet-induced . . . An exercise intervention also reversed the lipid accumulation seen in GV stage oocytes of HFD females However, delays in meiosis and disorganized MII spindles remained present Therefore, exercise is able to improve, but not reverse, damage imparted on oocytes as a result of an HFD and obesity
The effects of voluntary exercise on oocyte quality in a diet-induced . . . By utilizing an exercise intervention on an HFD, we determined only lipid content, and lipid metabolism is changed in GV oocytes Moving forward, interventions to improve oocyte quality may need to be more targeted to the oocyte specifically
The effects of voluntary exercise on oocyte quality in a diet-induced . . . Because the reproductive consequences of obesity are likely rooted at the oocyte level, and exercise is beneficial to both mother and offspring, we hypothesized that even without at change in diet, the physiological benefits of exercise would be reflected in oocytes
The effects of voluntary exercise on oocyte quality in a diet-induced . . . Therefore, exercise is able to improve, but not reverse, damage imparted on oocytes as a result of a high fat diet and obesity By utilizing an exercise intervention on a HFD, we determined only lipid content and lipid metabolism is changed in GV oocytes
Results - The Effects of Voluntary Exercise on Oocyte Quality in a Diet . . . Previously, our lab and others have shown that mice maintained on a high-fat diet (HFD) became obese and had damaged oocytes To determine whether exposure to voluntary exercise could reverse any of the defects, we exposed mice to either HFD or control chow diet (CD) for 12 weeks beginning at 4 weeks of age
The effects of voluntary exercise on oocyte quality in a diet-induced . . . The results suggest that the negative effects of an obesogenic diet on oocyte quality are not reversible, despite reversal of metabolic parameters, and may provide better insight when counselling obese women regarding reproductive options and success
The effects of voluntary exercise on oocyte quality in a diet-induced . . . The results suggest that the negative effects of an obesogenic diet on oocyte quality are not reversible, despite reversal of metabolic parameters, and may provide better insight when counselling obese women regarding reproductive options and success