120295: Low-density Lipoprotein Cholesterol (Direct) | Labcorp LDL cholesterol measurement, in conjunction with other lipid measurements, has been shown to be useful in assessing the risk of coronary heart disease (CHD) The National Cholesterol Education Program (NCEP) 1 has stated that LDL cholesterol should be the “key index” in determination of CHD risk
Directly Measured vs. Calculated Low-Density Lipoprotein . . . Cox regression analysis showed compared the correct estimation group, underestimation of LDL-C by the Martin Hopkins equation did not reduce all-cause mortality (HR 1 26, 95% CI: 0 72–2 20, P = 0 4), recurrent AMI (HR 1 24, 95% CI: 0 69–2 21, P = 0 5), and MACE (HR 1 02, 95% CI: 0 83–1 26, P = 0 9)
Direct LDL Cholesterol - Testing. com Direct measurement of LDL cholesterol is not a routine cholesterol test Instead, it is most often used if you need a cholesterol test but may have high levels of fat molecules called triglycerides High triglycerides can invalidate the formula used to calculate LDL cholesterol
Direct LDL Cholesterol Assay vs. Estimated Equations in . . . Equations, such as Friedewald, Martin–Hopkins, or Sampson, are often used instead to calculate LDL-C levels [4, 5] Equations have limitations, particularly for the calculation LDL-C≤70 mg dL or triglycerides levels (TG) ≥400 mg dL
ADLM guidance document on the measurement and reporting of . . . In summary, standard lipid panels should report 3 measured values: TC, TG, HDL-C, and 2 calculated parameters: LDL-C and non-HDL-C How Should the Lipid Panel Be Named? Ideally, test names for the lipid panel and its components should indicate the specific analyte being measured, the sample obtained, and method used when appropriate (4)
Best practice for LDL-cholesterol: when and how to calculate in using different methods of measuring LDL- C in these patients and it is therefore recommended that direct measurement of LDL-C might be more accurate in these situations 10 11 Direct assay of LDL cholesterol has also been shown to be more accurate than total cholesterol for lipoprotein screening
Difference between calculated and direct-measured low-density . . . We evaluated factors that caused differences between calculated low-density lipoprotein cholesterol (C-LDL-C) and direct-measured LDL-C (D-LDL-C) and compared them in subjects with diabetes mellitus (DM) or taking lipid-lowering medications